Dr. Karina Silina

Publications

2017-2024

Calvanese AL, Cecconi V, Stäheli S, Schnepf D, Nater M, Pereira P, Gschwend J, Heikenwälder M, Schneider C, Ludewig B, Silina K, van den Broek M. Sustained innate interferon is an essential inducer of tertiary lymphoid structures. Eur J Immunol. 2024 Oct;54(10):e2451207. doi: 10.1002/eji.202451207. Epub 2024 Jul 9. PMID: 38980268.

van Rijthoven M, Obahor S, Pagliarulo F, van den Broek M, Schraml P, Moch H, van der Laak J, Ciompi F, Silina K. Multi-resolution deep learning characterizes tertiary lymphoid structures and their prognostic relevance in solid tumors. Commun Med (Lond). 2024 Jan 5;4(1):5. doi: 10.1038/s43856-023-00421-7.

Silina K. B cell-rich niches support stem-like CD8+ T cells in cancer microenvironment. Cancer Cell. 2023 May 8;41(5):824-825. doi: 10.1016/j.ccell.2023.04.007.

Sato Y, Silina K, van den Broek M, Hirahara K, Yanagita M. The roles of tertiary lymphoid structures in chronic diseases. Nat Rev Nephrol. 2023 Aug;19(8):525-537. doi: 10.1038/s41581-023-00706-z. Epub 2023 Apr 12.

Pagliarulo F, Cheng PF, Brugger L, van Dijk N, van den Heijden M, Levesque MP, Silina K*#, van den Broek M*. Molecular, Immunological, and Clinical Features Associated With Lymphoid Neogenesis in Muscle Invasive Bladder Cancer. Frontiers in Immunology 12 (2022)  *Equal contribution   #Corresponding author

Van Dijk N*, Gil-Jimenez A*, Silina K, Montfoort ML van, Einerhand S, Jonkman L, Voskuilen CS, Peters D, Sanders J, Lubeck Y, Broeks A, Hooijberg E, Vis DJ, van den Broek M, Wessels LFA, van Rhijn BWG, van der Heijden MS. The Tumor Immune Landscape and Architecture of Tertiary Lymphoid Structures in Urothelial Cancer. Frontiers in Immunology 12 (2021)   *Equal contribution

van Rijthoven, M., Balkenhol, M., Silina, K., van der Laak, J. & Ciompi, F. HookNet: multi-resolution convolutional neural networks for semantic segmentation in histopathology whole-slide images. Med. Image Anal. 68, (2021).

Sobottka B, Lorch A, Silina K, van den Broek M, Moch H. Renal cell carcinoma pathology in 2021: ‘new need for renal cancer immune profiling’. Cur Opin Urol 31 (3): 228-235. (2021)

Tallón de Lara P*, Castañón H*, Vermeer M, Núñez N, Silina K, Sobottka B, Urdinez J, Cecconi V, Yagita H, Movahedian Attar F, Hiltbrunner S, Glarner I, Moch H, Tugues S, Becher B, van den Broek M. CD39+PD-1+CD8+ T cells mediate metastatic dormancy in breast cancer. Nat Commun 12, 769 (2021)
*Equal contribution

van Dijk, N.*, Gil Jimenez, A*., Silina, K., Hendricksen, K., Smit, L., JM, de F., van Montfoort, M., van Rooijen, C., Peters, D., Broek, A., van der Poel, H., Bruining, A., Lubeck, Y., Sikorska, K., Boellaard, T., Kvistborg, P., Vis, D., Hooijberg, E., Schumacher, T., van den Broek, M., Wessels, L., Blank, C., van Rhijn, B. & van der Heijden, M. Preoperative ipilimumab plus nivolumab in locoregionally advanced urothelial cancer: the NABUCCO trial. Nat. Med. 26, 1839–1844 (2020)
*Equal contribution

Schadt L, Sparano C, Schweiger NA, Silina K, Cecconi V, Lucchiari G, Yagita H, Guggisberg E, Saba S, Nascakova Z, Barchet W, van den Broek M. Cancer-Cell-Intrinsic cGAS Expression Mediates Tumor Immunogenicity. Cell Reports 29 (5):1236-1248.e7 (2019)
Wagner J, Rapsomaniki MA, Chevrier S, Anzeneder T, Langwieder C, Dykgers A, Rees M, Ramaswamy A, Muenst S, Soysal SD, Jacobs A, Windhager J, Silina K, van den Broek M, Dedes KJ, Rodríguez Martínez M, Weber WP, Bodenmiller B. A Single-Cell Atlas of the Tumor and Immune Ecosystem of Human Breast Cancer. Cell 177 (5): 1330-1345.e18 (2019)

Silina, K*., Soltermann, A., Movahedian Attar, F., Casanova, R., Uckeley, Z. M., Thut, H., Wandres, M., Isajevs, S., Cheng, P. F., Curioni Fontecedro, A., Foukas, P., Levesque, M. P., Moch, H., Line, A. & van den Broek, M. Germinal centers determine the prognostic relevance of tertiary lymphoid structures and are impaired by corticosteroids in lung squamous cell carcinoma. Cancer Res 78, 1308–1320 (2018).
*Journal cover image

Posch, F.*, Silina, K.*, Leibl, S., Mundlein, A., Moch, H., Siebenhuner, A., Samaras, P., Riedl, J., Stotz, M., Szkandera, J., Stoger, H., Pichler, M., Stupp, R., van den Broek, M., Schraml, P., Gerger, A., Petrausch, U. & Winder, T. Maturation of tertiary lymphoid structures and recurrence of stage II and III colorectal cancer. Oncoimmunology 7, e1378844 (2018).  *Equal contribution

Silina, K.*#, Burkhardt, C., Casanova, R., Solterman, A. & van den Broek, M. A Quantitative Pathology Approach to Analyze the Development of Human Cancer-Associated Tertiary Lymphoid Structures. Methods Mol Biol 1845, 71–86 (2018).
*Invited contribution  #Corresponding author

Garaud S, Zayakin P, Buisseret L, Rulle U, Silina K, de Wind A, van den Eyden G, Larsimont D, Willard-Gallo K, Linē A. Antigen specificity and clinical significance of IgG and IgA autoantibodies produced in situ by tumor-infiltrating B cells in breast cancer. Front Immunol 9:1-12 (2018)

Chevrier, S., Levine, J*. H., Zanotelli, V. R. T.*, Silina, K., Schulz, D., Bacac, M., Ries, C. H., Ailles, L., Jewett, M. A. S., Moch, H., van den Broek, M., Beisel, C., Stadler, M. B., Gedye, C., Reis, B., Pe’er, D. & Bodenmiller, B. An Immune Atlas of Clear Cell Renal Cell Carcinoma. Cell 169, 736-749 e18 (2017)
*Equal contribution

Meistere I, Werner S, Zayakin P, Silina K, Rulle U, Pismennaja A, Santare D, Kikuste I, Isajevs S, Leja M, Kupcinskas L, Kupcinskas J, Jonaitis L, Wu CY, Brenner H, Line A, Kalnina Z. The Prevalence of Cancer-Associated Autoantibodies in Patients with Gastric Cancer and Progressive Grades of Premalignant Lesions. Cancer Epidemiol Biomarkers Prev 26 (10):1564-1574 (2017)