PD Dr. Jörg Scheuermann

Research Interests

• DNA-encoded chemical library (DEL) technology:
  - DEL Library construction
    (single- and dual-pharmacophore DEL libraries, macrocyclic DELs, novel DEL set-ups)
  - DEL chemistry
  - DEL screening technology
  - DEL hit validation strategies

• DELs for PROTAC technology

• Discovery and Translation of DEL-derived hits against targets of pharmaceutical interest,
  e.g. tumor-associated targets

• Small-molecule drug conjugates (SMDCs)

Education & Positions held

2020 - today
Principal Investigator / Group head "DNA-encoded chemical libraries / DEL technology"
and Privatdozent at ETH Zurich

2018
ETH Habilitation Thesis "DNA-encoded Chemical Library Technology for Drug Discovery"

2009-2020
Senior Scientist in the group of Prof. Dario Neri at ETH Zurich
Development of DNA-encoded chemical library technology

2003-2008
Postdoctoral fellow in the group of Prof. Dario Neri at ETH Zurich
Development of DNA-encoded chemical library technology

1999-2003
PhD in the group of Prof. Dario Neri at ETH Zurich
PhD Thesis: "Isolation of binding molecules to the EDB domain of fibronectin, a marker of angiogenesis"

1999
Diploma in Chemistry, ETH Zurich
Diploma Thesis: "chemical synthesis of a structural analogue of Xanthosin, a potential building block for an expanded genetic code"
Supervisor: Prof. S. A. Benner

Publications